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Thermoregulation in Parkinson disease.

Elizabeth A Coon1, Phillip A Low1

  • 1Department of Neurology, Mayo Clinic, Rochester, MN, United States.

Handbook of Clinical Neurology
|November 22, 2018
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Summary

Parkinson disease (PD) involves autonomic dysfunction, specifically thermoregulation issues like abnormal sweating and temperature sensation. Objective tests reveal deficits that impact quality of life and can help differentiate PD from other neurodegenerative disorders.

Keywords:
Parkinson diseaseautonomichyperhidrosisparkinsonism-hyperpyrexiathermoregulation

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Area of Science:

  • Neurology
  • Autonomic Neuroscience

Background:

  • Autonomic dysfunction, including thermoregulatory symptoms, has been recognized in Parkinson disease (PD) since the late 19th century.
  • These symptoms gained more attention with objective autonomic function testing in the post-levodopa era.

Purpose of the Study:

  • To explore the role of thermoregulatory dysfunction in Parkinson disease.
  • To understand the pathophysiology and clinical implications of these symptoms.

Main Methods:

  • Objective thermoregulatory testing in Parkinson disease patients.
  • Correlation of thermoregulatory deficits with autonomic and disease severity.

Main Results:

  • Objective testing reveals deficits in sweating and vasomotor tone in PD patients.
  • These deficits often correlate with other autonomic impairments.
  • Thermoregulatory tests can aid in differentiating PD from other neurodegenerative conditions.

Conclusions:

  • Thermoregulatory dysfunction in PD involves central (brainstem, hypothalamus) and peripheral mechanisms.
  • Alpha-synuclein pathology and peripheral neuropathy contribute to these issues.
  • Thermoregulatory disorders significantly impact patient quality of life and can be life-threatening.