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Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

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Thermoregulation in amyotrophic lateral sclerosis.

Luc Dupuis¹, Åsa Petersen², Patrick Weydt³

¹Faculty of Medicine, University of Strasbourg, Strasbourg, France.

Handbook of Clinical Neurology

|November 22, 2018

Summary

Amyotrophic lateral sclerosis (ALS), a motor neuron disease, shows links to thermoregulation issues. Further research is needed to explore body temperature changes as potential biomarkers for ALS progression.

Keywords:

PGC-1α SOD1 TDP-43 amyotrophic lateral sclerosis body temperature brown adipose tissue dynein energy homeostasis frontotemporal dementia skeletal muscle sympathetic nervous system

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Area of Science:

Neuroscience
Physiology

Background:

Amyotrophic lateral sclerosis (ALS) is a primary adult-onset motor neuron disease.
ALS shares clinical, pathological, and genetic links with frontotemporal dementia, a leading cause of dementia.
Thermoregulation is a critical homeostatic function involving complex neural and physiological systems.

Purpose of the Study:

To review existing evidence connecting thermoregulation and amyotrophic lateral sclerosis (ALS).
To highlight the potential role of thermoregulatory dysfunction in ALS pathogenesis and progression.
To advocate for direct investigation into body temperature regulation in ALS.

Main Methods:

Literature review of studies on ALS and thermoregulation.
Analysis of the impact of ALS progression on brain regions controlling body temperature.
Examination of thermoregulatory disturbances in animal models of ALS.

Main Results:

ALS progression affects key brain areas governing body temperature control.
Dysfunctional thermoregulation is observed in animal models of ALS, linked to energy homeostasis disruption.
Indirect evidence suggests a connection between ALS and impaired body temperature regulation.

Conclusions:

While not a classic symptom, thermoregulation may be significantly impacted by ALS.
Investigating thermoregulation could reveal potential biomarkers for ALS.
Thermoregulatory system analysis may offer insights into modifying ALS disease progression.