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Related Concept Videos

Thermoregulation01:26

Thermoregulation

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Acute Kidney Injury I: Introduction01:22

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Related Experiment Video

Updated: Feb 2, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
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Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

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Thermoregulation in brain injury.

Ram Gowda1, Matthew Jaffa1, Neeraj Badjatia1

  • 1Program in Trauma, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.

Handbook of Clinical Neurology
|November 22, 2018
PubMed
Summary

Brain injury disrupts temperature control through various mechanisms. While targeted temperature management (TTM) shows promise, further research is needed to identify optimal patient subsets for fever management in critical neurological care.

Keywords:
brain injuryfeverhypothermiatargeted temperature management (TTM)thermoregulationvascular lesion

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Area of Science:

  • Neuroscience
  • Critical Care Medicine
  • Neurology

Background:

  • Thermoregulatory dysfunction is common after ischemic stroke, hemorrhagic stroke, and traumatic brain injury.
  • Mechanisms include hypothalamic injury, altered cerebral blood flow, metabolic issues, and neuroinflammation.
  • Temperature instability significantly impacts outcomes in patients with brain injuries.

Purpose of the Study:

  • To explore the mechanisms of thermoregulatory dysfunction post-brain injury.
  • To evaluate the efficacy and patient subset selection for targeted temperature management (TTM).
  • To discuss the role of fever management in critically ill neurological patients.

Main Methods:

  • Review of existing literature on thermoregulation and brain injury.
  • Analysis of factors contributing to temperature dysregulation.
  • Discussion of clinical trial outcomes regarding TTM.

Main Results:

  • Heterogeneity of brain injury complicates TTM efficacy.
  • Clinical trials have not consistently demonstrated improved patient outcomes with TTM.
  • Fever is detrimental in critically ill neurological patients.

Conclusions:

  • Aggressive fever management is crucial for critically ill neurological patients.
  • Further research is needed to identify specific patient groups who benefit from TTM.
  • Understanding thermoregulatory mechanisms is key to improving patient care after brain injury.