Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Therapy00:59

Gene Therapy

27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Group Therapy01:26

Group Therapy

443
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
443
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

5.2K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.2K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

3.4K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.4K
Acute Pharyngitis01:30

Acute Pharyngitis

4.2K
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
4.2K
Cancer Therapies02:49

Cancer Therapies

10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Methods for randomized, blinded, controlled evaluation of putative disease interventions in multilaboratory, preclinical assessment networks.

Lab animal·2026
Same author

Methods for randomized, blinded, controlled evaluation of putative disease interventions in multilaboratory, preclinical assessment networks.

Lab animal·2026
Same author

Feasibility of a Multi-Laboratory Model of Middle Cerebral Artery Thromboembolic Stroke with Thrombolysis: TE-MCAo.

Translational stroke research·2026
Same author

Validation of the National Institutes of Health Stroke Scale in Intracerebral Hemorrhage.

Stroke (Hoboken, N.J.)·2026
Same author

The Stroke Preclinical Assessment Network Multi-laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo.

Journal of visualized experiments : JoVE·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Related Experiment Video

Updated: Feb 2, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.7K

Hypothermia in acute ischemic stroke therapy.

Fernando Mayor Basto1, Patrick Lyden1

  • 1Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Handbook of Clinical Neurology
|November 22, 2018
PubMed
Summary

Therapeutic hypothermia (TH) shows neuroprotection in animal models but human trial results vary. Understanding optimal conditions for TH in clinical settings is critical for its effective use in treating brain injuries.

Keywords:
neuroprotectionstroketherapeutic hypothermia

More Related Videos

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research
07:34

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

3.3K
Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

1.6K

Related Experiment Videos

Last Updated: Feb 2, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.7K
Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research
07:34

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

3.3K
Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

1.6K

Area of Science:

  • Neuroscience
  • Critical Care Medicine
  • Neurology

Background:

  • Therapeutic hypothermia (TH) is a well-established neuroprotective strategy in experimental models of cerebral ischemia.
  • TH demonstrates significant benefits in human cases of neonatal hypoxic-ischemic injury and global cerebral ischemia post-cardiac arrest.
  • Current guidelines recommend TH for specific patient groups following global ischemia.

Purpose of the Study:

  • To investigate the reasons behind the variable success of therapeutic hypothermia in human clinical trials.
  • To reconcile the discrepancy between potent neuroprotection in animal studies and inconsistent outcomes in human trials for stroke and head trauma.
  • To identify critical factors influencing TH efficacy in clinical settings.

Main Methods:

  • Review of preclinical studies demonstrating the efficacy of TH in animal models of cerebral ischemia.
  • Analysis of clinical trial data for therapeutic hypothermia in neonatal hypoxic-ischemic injury, cardiac arrest, head trauma, and stroke.
  • Comparison of TH parameters (timing, duration, target temperature) between successful and unsuccessful human trials.

Main Results:

  • Preclinical studies consistently show TH is effective when initiated early, maintained for a short duration, and at a deep target temperature.
  • Clinical trials for cardiac arrest, head trauma, and stroke have yielded inconsistent results, with some failing to demonstrate significant benefits.
  • A recent study comparing target temperatures of 33-36°C in cardiac arrest patients did not show significant effects.

Conclusions:

  • The efficacy of therapeutic hypothermia in humans may depend on specific parameters, including precise timing, duration, and target temperature, mirroring findings in animal models.
  • Further research is essential to elucidate the fundamental mechanisms and optimal application of TH for various neurological conditions.
  • Understanding these critical factors is crucial for refining TH protocols and improving patient outcomes in neuroprotection.