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Related Concept Videos

Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Assessing Body Temperature - Temporal Artery01:19

Assessing Body Temperature - Temporal Artery

Here is a stepwise guide to assessing the body temperature at the temporal artery using a temporal artery thermometer
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.  
Step 3: Assess the patient's forehead...
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
Introduction to Special Senses01:26

Introduction to Special Senses

Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive functions.
Tactile and Chemical Senses01:27

Tactile and Chemical Senses

Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex. This...

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Related Experiment Video

Updated: Jun 30, 2026

A Tactile Automated Passive-Finger Stimulator (TAPS)
19:44

A Tactile Automated Passive-Finger Stimulator (TAPS)

Published on: June 3, 2009

Sensing danger through a "finger".

Xiaojing Ma1,2

  • 1Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY xim2002@med.cornell.edu.

The Journal of Experimental Medicine
|November 22, 2018
PubMed
Summary
This summary is machine-generated.

Cellular nucleic acid-binding protein (Cnbp) acts as a novel regulator of interleukin-12β (IL-12β) transcription. This finding impacts understanding of Th1-mediated immunity, host defense, and inflammatory diseases.

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Related Experiment Videos

Last Updated: Jun 30, 2026

A Tactile Automated Passive-Finger Stimulator (TAPS)
19:44

A Tactile Automated Passive-Finger Stimulator (TAPS)

Published on: June 3, 2009

Measuring Attentional Biases for Threat in Children and Adults
08:25

Measuring Attentional Biases for Threat in Children and Adults

Published on: October 19, 2014

Capturing Dynamic Finger Gesturing with High-resolution Surface Electromyography and Computer Vision
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Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Interleukin-12 (IL-12) is crucial for Th1-mediated immune responses.
  • Dysregulation of IL-12 production is implicated in inflammatory diseases.
  • Transcriptional regulation of IL-12 is complex and not fully understood.

Purpose of the Study:

  • To investigate the role of cellular nucleic acid-binding protein (Cnbp) in regulating IL-12 transcription.
  • To elucidate the involvement of Cnbp in Th1-mediated immune responses.
  • To explore the implications of Cnbp in host defense and inflammatory conditions.

Main Methods:

  • Gene expression analysis
  • Chromatin immunoprecipitation assays
  • Cellular and animal models of immune response

Main Results:

  • Chen et al. identified Cnbp as a novel transcriptional regulator of IL-12β.
  • Cnbp directly influences IL-12β gene transcription.
  • Cnbp plays a significant role in IL-12-driven Th1 immune responses.

Conclusions:

  • Cnbp is a key regulator of IL-12β transcription.
  • Cnbp's function has significant implications for host defense mechanisms.
  • Targeting Cnbp may offer therapeutic strategies for inflammatory diseases.