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Identifying and Eliminating Laboratory Contamination by Topical Testosterone Therapeutics
Jonathan R Genzen1,2, Sonia L La'ulu3, Sara P Wyness3
1ARUP Laboratories, Salt Lake City, UT; jonathan.genzen@path.utah.edu.
Clinical Chemistry
|November 22, 2018
Summary
Topical drug contamination in labs can interfere with diagnostic tests. A case study on testosterone contamination highlights challenges in detection and resolution, leading to revised lab procedures.
Area of Science:
- Clinical Chemistry
- Laboratory Medicine
- Environmental Contamination
Background:
- Topical medications, both prescription and over-the-counter, are widely used.
- Contamination of clinical laboratory workspaces by these drugs poses a risk for diagnostic test interference.
- Localized contamination by topical hormonal drugs, such as testosterone, presents unique identification and resolution challenges.
Purpose of the Study:
- To present a case study of localized workspace contamination by a topical hormonal drug (testosterone).
- To highlight the difficulties in identifying and resolving such contamination events.
- To demonstrate the impact of contamination on diagnostic testing and laboratory operations.
Main Methods:
- Precision studies and instrument servicing were conducted.
- Instrument replacement, airflow analysis, and environmental dust sampling were performed.
- Customized methods for workspace monitoring and cleaning were developed and implemented.
Main Results:
- The investigation successfully identified the source and extent of testosterone contamination.
- Various analytical and environmental techniques were employed to trace the contamination.
- Effective monitoring and cleaning protocols were established.
Conclusions:
- Workspace contamination by topical drugs is a significant concern in clinical laboratories.
- A systematic approach involving advanced analytical techniques and environmental assessment is crucial for resolution.
- Revised laboratory policies and procedures are essential to mitigate future risks associated with topical drug contamination.
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