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Pattern Recognition Receptors and the Host Cell Death Molecular Machinery
Gustavo P Amarante-Mendes1,2, Sandy Adjemian3,4, Laura Migliari Branco5,6
1Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
Frontiers in Immunology
|November 22, 2018
Summary
Pattern Recognition Receptors (PRRs) detect pathogen molecules and damage signals, initiating innate immune responses. This review explores how PRR activation influences programmed cell death and inflammation.
Area of Science:
- Immunology
- Cell Biology
Background:
- Pattern Recognition Receptors (PRRs) are crucial for innate immunity, recognizing Pathogen-Associated Molecular Patterns (PAMPs) and Damage-Associated Molecular Patterns (DAMPs).
- These receptors predate adaptive immunity and trigger microbicidal and pro-inflammatory responses.
- Programmed cell death is an ancient mechanism for removing damaged or infected cells, impacting immune responses.
Purpose of the Study:
- To review the molecular interplay between cell death pathways and Pattern Recognition Receptor (PRR) signaling.
- To elucidate how PRR activation by PAMPs and DAMPs influences various forms of cell death.
Main Methods:
- Literature review focusing on molecular mechanisms.
- Analysis of signaling pathways connecting PRRs and cell death machinery.
Main Results:
- PRR engagement by PAMPs/DAMPs modulates inflammatory and microbicidal functions.
- Different cell death modalities exert distinct effects on innate and adaptive immunity.
- Cross-talk exists between PRR-initiated signals and the molecular machinery governing cell death.
Conclusions:
- Understanding the interplay between PRRs and cell death is vital for comprehending innate immunity.
- This interaction influences the resolution of infection and tissue homeostasis.
- Further research into these molecular connections can reveal therapeutic targets.
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