Related Experiment Video
Updated: Feb 2, 2026
Cerebellar Regional Dissection for Molecular Analysis
Published on: December 5, 2020
Clinical Characteristics of Cerebellar Infarction Due to Arterial Dissection
Joji Inamasu1, Shunsuke Nakae1, Yoko Kato1
1Department of Neurosurgery, Fujita Health University Hospital, Toyoake, Japan.
Insights
Arterial dissection (AD) caused about 30% of cerebellar infarctions (CI). Younger patients experiencing acute pain are more likely to have AD, often involving the intracranial vertebral artery (VA).
Area of Science:
- Neurology
- Vascular Neurology
- Cerebrovascular Diseases
Background:
- Arterial dissection (AD) of the vertebral artery (VA) or its branches can lead to posterior circulation ischemic stroke.
- Clinical and radiological features of AD-related cerebellar infarction (CI) are not well-documented.
Purpose of the Study:
- To investigate the clinical and radiological characteristics of patients with AD-related CI.
- To identify factors associated with AD in patients with CI.
Main Methods:
- Retrospective analysis of 49 patients with CI from April 2008 to March 2015.
- Patients were divided into AD and non-AD groups for comparison of demographics and symptoms.
- Multivariate regression analysis was used to identify variables correlating with AD.
Main Results:
- 14 patients had AD, and 35 did not. The AD group was younger (55.0 vs. 69.7 years) and more likely to report acute pain (86% vs. 17%).
- Younger age, acute pain at onset, and male sex correlated with AD.
- AD locations included extracranial VA (n=3), intracranial VA (n=8), PICA (n=3), and SCA (n=1).
Conclusions:
- AD accounted for approximately 30% of CI in this cohort.
- Acute pain is a potential indicator for identifying AD-related CI.
- While intracranial VA dissection is common, extracranial VA and PICA dissections should also be considered, even with subtle radiological findings.
Objectives And Background:
Arterial dissection (AD) of the vertebral artery (VA) or its branches may cause ischemic stroke of the posterior circulation. However, clinical and radiological characteristics of patients with AD-related cerebellar infarction (CI) have rarely been reported.
Methods:
Forty-nine patients with CI admitted to our department from April 2008 to March 2015 were identified from our database. After dichotomization into the AD and non-AD group, their demographics and presenting symptoms were compared. Subsequently, a multivariate regression analysis was performed to identify variables that correlated with AD.
Results:
During the 7-year period, 14 and 35 patients were identified in the AD and non-AD group, respectively. The AD group was significantly younger than the non-AD group (55.0 ± 16.3 vs. 69.7 ± 10.7 years, P = 0.001) and was also more likely to experience acute pain at onset (86% vs. 17%, P < 0.001). Using a multivariate regression analysis, these two variables and the male sex were found to correlate with AD. AD was located in extracranial VA (n = 3); intracranial VA (n = 8); posterior inferior cerebellar artery (PICA) (n = 3); and superior cerebellar artery (n = 1). Identification of AD was delayed in one patient with an extracranial VA and one patient with a PICA dissection.
Conclusions:
AD was responsible for approximately 30% of CI in our cohort. Pain at onset may be a useful symptom to identify patients with AD-related CI. While intracranial VA was the most common location of AD, physicians should be aware of the possibility of extracranial VA or PICA dissection in patients with seemingly unremarkable radiological findings.
Related Concept Videos
01:30Coronary Artery Disease III: Clinical Manifestations
01:23Characteristics of Life
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
01:20Characteristics of Fluids
01:31Characteristics of Fluids
Fluids, which include both liquids and gases, are substances that deform continuously under shearing stress. For example, water and oil are liquids with molecules that can...
01:17Characteristics of BJT
For input characteristics, the base-emitter voltage is varied, maintaining a constant collector-emitter voltage. This setup reveals a Shockley-type dependence of the collector current on...