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Updated: Feb 2, 2026

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Published on: May 2, 2017
Appearance of CNS histoplasmosis on 18F-FDG PET/CT with MRI correlation
William Makis1, Rajan Rakheja2, Stephan Probst2
1Department of Diagnostic Imaging, Cross Cancer Institute, Edmonton, AB, Canada.
Abstract:
Disseminated histoplasmosis is an opportunistic infection encountered in immunocompromised patients such as those with human immunodeficiency virus infection/acquired immune deficiency syndrome. Involvement of the central nervous system (CNS) can occur in 5-20% of cases of disseminated histoplasmosis, and CNS histoplasmosis can be very difficult to diagnose via conventional imaging modalities such as CT or MRI. The role of 18F-fludeoxyglucose positron emission tomography/CT scan in the diagnosis of CNS histoplasmosis has not been established. A 66-year-old female presented with dizziness and unsteady gait and was diagnosed with human immunodeficiency virus infection and CNS histoplasmosis. In this report, we present the MRI and 18F-fludeoxyglucose positron emission tomography/CT image findings.
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