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Updated: Feb 2, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Primary intraosseous squamous cell carcinoma of the mandible: a case with atypical imaging features
João Lopes Dias1, Alexandra Borges2, Rafaela Lima Rego3
1Department of Radiology, Hospital de São José, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.
Abstract:
Primary intraosseous squamous cell carcinoma is a rare malignant tumour that exclusively arises within the jaws. Its diagnosis requires an appropriate clinical, imaging and histological correlation. The exclusion of primary oral mucosa lesions and metastatic disease is mandatory. We report an atypical imaging appearance of this uncommon entity, characterized by new bone formation and periosteal reaction that resemble sarcomatous or malignant odontogenic tumours. A comprehensive discussion on the embryological principles of primary intraosseous squamous cell carcinoma is also provided.
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