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Related Experiment Video

Updated: Feb 2, 2026

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
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Non-contact dynamic diffuse optical tomography imaging system for evaluating lower extremity vasculature.

J W Hoi1, H K Kim2, C J Fong1

  • 1Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 500 W. 120th St., New York, NY 10027, USA.

Biomedical Optics Express
|November 22, 2018
PubMed
Summary

A new non-contact imaging system uses diffuse optical tomography to evaluate lower extremity vasculature. This dynamic imaging shows potential for assessing blood flow and perfusion in the foot.

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Area of Science:

  • Biomedical optics
  • Medical imaging
  • Vascular imaging

Background:

  • Assessing lower extremity vasculature is crucial for diagnosing and managing peripheral vascular diseases.
  • Current imaging techniques may have limitations in dynamic perfusion assessment.
  • Diffuse optical tomography (DOT) offers a non-invasive approach to probe tissue optical properties.

Purpose of the Study:

  • To present a novel multi-view, non-contact, dynamic diffuse optical tomographic (DOT) imaging system.
  • To detail the system's design, implementation, and data acquisition methods.
  • To evaluate the system's performance for clinical application in lower extremity vasculature.

Main Methods:

  • Development of a multi-view DOT system utilizing a single CCD camera and a mirror system.
  • Simultaneous acquisition of diffusely reflected and transmitted light.
  • Image reconstruction algorithms for dynamic perfusion assessment.
  • Validation using numerical simulations and optical phantoms.

Main Results:

  • The system successfully acquired and reconstructed dynamic diffuse optical data.
  • Performance evaluation through simulations and phantom studies demonstrated system feasibility.
  • In vivo measurements on a healthy foot showed the system's potential for perfusion assessment.

Conclusions:

  • The developed multi-view non-contact DOT system is a promising tool for dynamic vascular imaging.
  • The system has the potential for clinical evaluation of perfusion in lower extremities.
  • Further studies are warranted to explore its diagnostic capabilities in various vascular conditions.