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Lymphangiography and Post-lymphangiographic Multidetector CT for Preclinical Lymphatic Interventions in a Rabbit

Tomohiro Matsumoto1,2, Kosuke Tomita1, Shunto Maegawa1,2

  • 1Department of Radiology, Tokai University Hachioji Hospital, Tokai University School of Medicine, 1838 Ishikawa-machi, Hachioji, Tokyo, 192-0032, Japan.

Cardiovascular and Interventional Radiology
|November 22, 2018
PubMed
Summary
This summary is machine-generated.

Lymphangiography in rabbits is feasible, with post-procedure multidetector CT (MDCT) offering good lymphatic system visibility for preclinical interventions.

Keywords:
LipiodolLymphangiographyLymphatic interventionsPost-lymphangiographic multidetector CT

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Area of Science:

  • Medical Imaging
  • Vascular Biology
  • Preclinical Research

Background:

  • The lymphatic system's role in disease necessitates advanced imaging techniques.
  • Preclinical models are crucial for developing novel interventional strategies.

Purpose of the Study:

  • To assess the feasibility of lymphangiography.
  • To evaluate lymphatic system visibility using post-lymphangiographic multidetector CT (MDCT) in a rabbit model.
  • To determine the utility of this technique for preclinical lymphatic interventions.

Main Methods:

  • Lymphangiography was performed via the popliteal lymph node or vessel in six rabbits.
  • Lipiodol was used as a contrast agent.
  • Post-procedure MDCT scans were analyzed using 3D maximum intensity projection, with lymphatic structures scored by three reviewers.

Main Results:

  • Successful lymphangiography was achieved in all rabbits.
  • The popliteal lymph node was detected in 90% of cases, with 89% visualization of the lymphatic system.
  • Good to excellent visualization scores were obtained for major lymphatic vessels and the cisterna chyli.

Conclusions:

  • Lymphangiography is a feasible technique in this rabbit model.
  • Post-lymphangiographic MDCT provides adequate lymphatic system detail for preclinical intervention planning.
  • This imaging approach supports the development of new lymphatic interventions.