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Updated: Feb 2, 2026

Electrochemotherapy of Tumours
Published on: December 15, 2008
Short-acquisition-time JPRESS and its application to paediatric brain tumours
Dominic Carlin1,2, Ben Babourina-Brooks1,2, Theodoros N Arvanitis1,2,3
1Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, West Midlands, UK.
Objective:
To develop and assess a short-duration JPRESS protocol for detection of overlapping metabolite biomarkers and its application to paediatric brain tumours at 3 Tesla.
Materials And Methods:
The short-duration protocol (6 min) was optimised and compared for spectral quality to a high-resolution (38 min) JPRESS protocol in a phantom and five healthy volunteers. The 6-min JPRESS was acquired from four paediatric brain tumours and compared with short-TE PRESS.
Results:
Metabolite identification between the 6- and 38-min protocols was comparable in phantom and volunteer data. For metabolites with Cramer-Rao lower bounds > 50%, interpretation of JPRESS increased confidence in assignment of lactate, myo-Inositol and scyllo-Inositol. JPRESS also showed promise for the detection of glycine and taurine in paediatric brain tumours when compared to short-TE MRS.
Conclusion:
A 6-min JPRESS protocol is well tolerated in paediatric brain tumour patients. Visual inspection of a 6-min JPRESS spectrum enables identification of a range of metabolite biomarkers of clinical interest.
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