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Precision medicine in renal stone-formers
Fay Hill1, John A Sayer2,3,4
1Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle, NE1 3BZ, UK.
Precision medicine offers tailored approaches for renal stone formers, optimizing diagnosis and management. Personalized therapies, guided by genetic discoveries in monogenic stone disorders, improve prevention and treatment outcomes.
Area of Science:
- Nephrology
- Genetics
- Personalized Medicine
Background:
- Renal stone disease affects a significant portion of the population.
- Current management strategies for renal stone formers lack personalization.
- Genetic factors play a crucial role in the development of certain stone disorders.
Purpose of the Study:
- To define precision medicine approaches applicable to renal stone formers.
- To illustrate the benefits of personalized therapies for optimizing diagnosis and management.
- To highlight the role of gene discovery in advancing personalized treatment for stone disorders.
Main Methods:
- Review of precision medicine principles.
- Application of these principles to renal stone formation.
- Case examples using monogenic stone disorders.
Main Results:
- Precision medicine enables optimized diagnosis and management strategies for renal stone formers.
- Personalized therapies demonstrate improved prevention and treatment efficacy.
- Genetic insights are key to tailoring interventions for specific patient subgroups.
Conclusions:
- Precision medicine holds significant promise for revolutionizing the care of renal stone formers.
- Personalized therapeutic strategies based on genetic profiles can enhance patient outcomes.
- Further research into genetic underpinnings will drive the advancement of precision nephrology.
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