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Association Between TG-to-HDL-C Ratio and In-Stent Stenosis Under Optical Coherence Tomography Guidance

Ya Li1,2, Peng Jin1,3, Fangjie Hou1,4

  • 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Journal of Medical Systems
|November 22, 2018
PubMed

Insights

The triglyceride-to-HDL-C ratio is a significant risk factor for in-stent restenosis (ISR). This ratio can help diagnose ISR, a common complication after stenting.

Area of Science:

  • Cardiology
  • Biochemistry
  • Medical Diagnostics

Background:

  • In-stent restenosis (ISR) is a significant complication following coronary artery stenting.
  • Identifying reliable biomarkers for ISR is crucial for patient management and risk stratification.

Purpose of the Study:

  • To investigate the association between the triglyceride-to-HDL-C ratio and the incidence of ISR.
  • To evaluate the diagnostic efficacy of the TG-to-HDL-C ratio for ISR.

Main Methods:

  • Retrospective study including 99 patients with ISR and 122 control patients with <50% coronary stenosis.
  • Biochemical analysis of triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) to calculate the TG/HDL-C ratio.
  • Optical coherence tomography (OCT) used for microscopic assessment of ISR in affected patients.

Main Results:

  • Male gender, diabetes mellitus, and a higher TG-to-HDL-C ratio were identified as significant risk factors for ISR.
  • Logistic regression analysis confirmed these risk factors.
  • The TG-to-HDL-C ratio demonstrated a diagnostic accuracy (ROC curve area) of 0.725 for ISR.

Conclusions:

  • The TG-to-HDL-C ratio is a valuable and independent risk factor for ISR.
  • This lipid ratio shows potential as a diagnostic tool for identifying patients at risk of ISR.
  • Further research may elucidate the precise mechanisms linking this ratio to restenosis.

Keywords:
Coronary heart diseaseIn-stent restenosisOptical coherence tomographyTG-to-HDL ratio

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