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Patch testing with alkyl glucosides: Concomitant reactions are common but not ubiquitous
Bevin Bhoyrul1, Lea Solman1,2, Stephen Kirk3
1Department of Dermatology, Chapel Allerton Hospital, Leeds, UK.
Contact Dermatitis
|November 22, 2018
Summary
Contact allergy to alkyl glucosides is common, especially in atopic patients. Many individuals react to multiple alkyl glucosides, highlighting the need for their inclusion in cosmetic allergy testing.
Area of Science:
- Dermatology
- Allergology
- Cosmetic Science
Background:
- Alkyl glucosides are mild surfactants widely used in cosmetics and household products.
- Contact allergy to alkyl glucosides may be underestimated, particularly in atopic individuals.
Purpose of the Study:
- To determine the frequency of contact allergy to alkyl glucosides.
- To identify cross-reactivity patterns among different alkyl glucosides.
Main Methods:
- Retrospective review of suspected allergic contact dermatitis (ACD) cases.
- Patch testing with a cosmetic series including five alkyl glucosides or a specific alkyl glucoside series.
- Data collected from two UK centers between November 2013 and April 2017.
Main Results:
- 1.04% of patients tested showed positive reactions to at least one alkyl glucoside.
- A high proportion (79.3%) of sensitized patients reacted to multiple alkyl glucosides.
- Atopic dermatitis was a common comorbidity (41.4%) in patients with alkyl glucoside allergy.
Conclusions:
- The prevalence of alkyl glucoside-induced ACD is significant.
- Frequent concomitant reactions between different alkyl glucosides were observed.
- Inclusion of alkyl glucosides in standard cosmetic patch test series is recommended.
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