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The relationship between platelet indices and ABO blood groups in healthy adults

Hakim Celik1, Ufuk Duzenli2, Mehmet Aslan3

  • 1Department of Physiology, Medical Faculty, Harran University, Sanliurfa, Turkey.

Journal of Clinical Laboratory Analysis
|November 22, 2018
PubMed

Insights

Individuals with O and A blood groups may have a lower risk of cardiovascular diseases (CVDs) due to lower mean platelet volume (MPV) and platelet distribution width (PDW). Further research is needed to confirm these findings.

Area of Science:

  • Hematology
  • Cardiovascular Medicine
  • Genetics

Background:

  • ABO blood groups are linked to cardiovascular diseases (CVDs).
  • Platelet indices, such as mean platelet volume (MPV) and platelet distribution width (PDW), are implicated in CVD development.
  • No prior studies have explored the relationship between ABO blood groups and platelet indices.

Purpose of the Study:

  • To investigate the association between ABO blood groups and platelet indices (MPV and PDW).

Main Methods:

  • 301 healthy volunteers (99 women, 202 men; age 32.59 ± 7.52 years) were included.
  • Blood groups were determined using the gel column method.
  • Platelet indices were analyzed using an automated blood counter.

Main Results:

  • No significant differences in age, gender, or Rh factors were found across ABO blood groups.
  • Mean platelet volume (MPV) was significantly lower in blood groups O and A compared to AB and B.
  • Platelet distribution width (PDW) was significantly lower in blood groups O and A compared to B. MPV was also lower in O compared to non-O blood groups.

Conclusions:

  • Individuals with O and A blood groups may have a reduced risk of CVDs compared to AB and B blood groups, given MPV and PDW are CVD markers.
  • Further large-scale prospective studies are required to validate these associations between ABO blood groups and platelet indices in relation to CVD risk.
Abstract

Keywords:
ABO blood groupscardiovascular diseasesmean platelet volumeplatelet distribution widthplatelet indices

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