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Sympathetic overactivity in dialysis patients-Underappreciated and clinically consequential
Neil A Hoye1, Luke C Wilson2, David L Jardine3
1Department of Renal Medicine, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.
Seminars in Dialysis
|November 22, 2018
Summary
Dialysis patients face high cardiovascular risks. Targeting sympathetic hyperactivity, linked to kidney disease, may offer new therapeutic strategies for this vulnerable population.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Physiology
Background:
- Cardiovascular morbidity and mortality are prevalent in dialysis patients.
- Established treatments are lacking, necessitating novel therapeutic approaches.
- Sympathetic hyperactivity, driven by diseased kidneys, is a known prognostic factor in dialysis patients.
Purpose of the Study:
- To review experimental and clinical data on sympathetic hyperactivity in dialysis.
- To highlight recent advancements in understanding this condition.
- To propose therapeutic interventions targeting sympathetic hyperactivity.
Main Methods:
- Narrative review of existing literature.
- Summary of experimental findings.
- Analysis of clinical data.
Main Results:
- Sympathetic hyperactivity is a long-recognized prognostic factor in dialysis.
- Previous therapeutic interventions have not been successful.
- Recent developments offer potential new avenues for treatment.
Conclusions:
- Interventions to reduce sympathetic hyperactivity warrant further investigation.
- Targeting sympathetic nervous system activity may improve outcomes for dialysis patients.
- This approach could benefit a high-risk patient group.
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