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Related Concept Videos

Concepts of Health and Illness01:29

Concepts of Health and Illness

Health is a condition of the body, mind, and spirit where an individual remains free from illness. Similarly, wellness is an active state, including living a lifestyle that promotes physical, mental, and emotional health. Physical health is critical for the overall well-being and can be affected by lifestyle, activity level, diet, and behavior. The highest attainable standard of health is a fundamental and universal human right. Consider Lisa, a fifteen-year-old born with congenital...
Models of Health Promotion and Illness Prevention II01:18

Models of Health Promotion and Illness Prevention II

The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
The agent-host-environment model states that disease results from...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...
Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...

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Platelet rich plasma in androgenetic alopecia: A systematic review.

Dermatologic therapy·2019
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Related Experiment Video

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Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells
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Salutogenesis and beyond.

Patrizia A d'Alessio1

  • 1AISA Therapeutics, Villejuif, France.

Dermatologic Therapy
|November 22, 2018
PubMed
Summary

This paper explores paradoxes in preventive medicine, defining salutogenesis and discussing aging biomarkers, antioxidants, the mTOR pathway, and senescent cell secretions. It proposes a new paradigm for health preservation and disease prevention.

Area of Science:

  • Preventive medicine
  • Biology of health
  • Health preservation

Background:

  • Salutogenesis is a key concept in health preservation and disease prevention.
  • Biological functions can exhibit indocility, presenting challenges to traditional preventive strategies.
  • Understanding these complexities is crucial for advancing medical paradigms.

Purpose of the Study:

  • To define salutogenesis and its origins.
  • To discuss four paradoxes within the biology of health.
  • To propose a new paradigm for preventive medicine.

Main Methods:

  • Literature review and hypothesis formulation.
  • Discussion of existing research on aging biomarkers.
  • Analysis of the role of antioxidants, the mTOR pathway, and senescent cell secretory profiles.
Keywords:
aginghealthlongevitypreventionsalutogenesis

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Main Results:

  • The paper defines salutogenesis and explores four key paradoxes in health biology.
  • Biomarkers of aging present complex interpretations.
  • Antioxidants exhibit dual effects, the mTOR pathway is crucial, and senescent cells have yin and yang effects.

Conclusions:

  • A new paradigm is needed for preventive medicine.
  • Addressing biological indocility and health paradoxes is essential.
  • Integrating these complex biological insights will advance health preservation.