Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histone acetylation: a step in gene activation.

G Vidali1, N Ferrari, U Pfeffer

  • 1Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.

Advances in Experimental Medicine and Biology
|January 1, 1988
PubMed
Summary

Cellular aging involves losing adaptability and homeostasis, potentially due to DNA changes or errors in protein synthesis. This chapter explores histone acetylation

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wildlife health surveillance: gaps, needs and opportunities.

Revue scientifique et technique (International Office of Epizootics)·2023
Same author

One year of surgical mask testing at the University of Bologna labs: Lessons learned from data analysis.

Separation and purification technology·2022
Same author

Ready-to-eat salads and berry fruits purchased in Italy contaminated by Cryptosporidium spp., Giardia duodenalis, and Entamoeba histolytica.

International journal of food microbiology·2022
Same author

Cytokines and parturition: investigating adiponectin, TNF-α, and IL-6 in mother-newborn pairs.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2022
Same author

Development of an integrated environmental monitoring protocol for SARS-CoV-2 contamination. Applications at the IRCSS San Martino Polyclinic Hospital in Genoa, Italy.

Environmental research·2022
Same author

Cost-effectiveness of a family-based multicomponent outpatient intervention program for children with obesity in Germany.

Public health·2020

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Cellular aging is characterized by reduced adaptability and impaired homeostasis.
  • Age-related decline can stem from DNA alterations, transcription errors, or protein synthesis issues.

Purpose of the Study:

  • To highlight histone acetylation's critical role in regulating chromatin structure.
  • To explain how histone acetylation influences gene transcription during cellular aging.

Main Methods:

  • Review of existing literature on cellular senescence and epigenetic modifications.
  • Analysis of molecular mechanisms linking histone acetylation to gene expression.

Main Results:

  • Histone acetylation is a significant epigenetic mechanism affecting chromatin accessibility.
  • Changes in histone acetylation patterns correlate with age-related transcriptional dysregulation.

Conclusions:

  • Histone acetylation is a key regulator of chromatin structure and gene transcription.
  • Targeting histone acetylation may offer strategies to modulate cellular aging processes.

Related Experiment Videos