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Omalizumab treatment in a 12 year-old girl with chronic spontaneous urticaria

Giuseppe Fabio Parisi1, Maria Papale1, Lucia Giovanna Tardino1

  • 1a Department of Clinical and Experimental Medicine , University of Catania , Catania , Italy.

The Journal of Dermatological Treatment
|November 22, 2018
PubMed

Background: Omalizumab is a recombinant humanized IgG monoclonal antibody, which binds the Fc region of free IgE prevent its binding to its high-affinity receptor (FcεR1) on mast cells and basophils. Omalizumab was approved as add-on therapy for moderate-to-severe persistent allergic asthma and for patients with chronic spontaneous urticaria resistant to antihistamine treatment. Patient and results: This article reports effective and safe treatment of a 12 years old girl with add-on omalizumab. On an initial dose of omalizumab of 300 mg once every 4 weeks, the patient experienced resolution of symptoms to a degree that exceeded the effect of previous treatments. Conclusion: Convincing evidence in support of the efficacy and safety of Omalizumab in the treatment of CSU in adolescent has accumulated over the past few years.

Keywords:
Chronic urticariaIgEantihistaminesomalizumab

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