Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Humoral Immune Responses

Humoral Immune Responses

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

Immune Response Against Viral Pathogens

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

Cells of the Innate Immune Response

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Novel Approach to Estimate the Impact of PCV20 Immunization in Children by Incorporating Indirect Effects to Generate the Number Needed to Vaccinate.

Vaccines·2025

Same author

Antibody persistence and revaccination recommendations of MenACWY-TT: a review of clinical studies assessing antibody persistence up to 10 years after vaccination.

Expert review of vaccines·2024

Same author

National and regional differences in meningococcal vaccine recommendations for individuals at an increased risk of meningococcal disease.

Expert review of vaccines·2023

Same author

Serum bactericidal activity against circulating and reference strains of meningococcal serogroup B in the United States: A review of the strain coverage of meningococcal serogroup B (MenB) vaccines in adolescents and young adults.

Human vaccines & immunotherapeutics·2023

Same author

Correlates of protection for meningococcal surface protein vaccines: lessons from the past.

Expert review of vaccines·2021

Same author

Translating meningococcal serogroup B vaccines for healthcare professionals.

Expert review of vaccines·2021

Search research articles

Related Experiment Video

Updated: Feb 2, 2026

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma

Published on: April 25, 2025

Experience implementing a university-based mass immunization program in response to a meningococcal B outbreak.

Blair Capitano¹, Krista Dillon², Andre LeDuc³

¹a Vaccines US Medical Affairs , Pfizer Inc , Collegeville , PA , USA.

Human Vaccines & Immunotherapeutics

|November 22, 2018

Summary

A Neisseria meningitidis serogroup B (MenB) outbreak on a university campus highlighted the challenges of mass immunization. Proactive student immunization is recommended for MenB outbreak prevention.

Keywords:

United States college campus mass immunization clinic meningococcal meningitis outbreak serogroup B student

More Related Videos

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Published on: July 14, 2023

Biocontained Carcass Composting for Control of Infectious Disease Outbreak in Livestock

Biocontained Carcass Composting for Control of Infectious Disease Outbreak in Livestock

Published on: May 6, 2010

Related Experiment Videos

Last Updated: Feb 2, 2026

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma

Published on: April 25, 2025

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Published on: July 14, 2023

Biocontained Carcass Composting for Control of Infectious Disease Outbreak in Livestock

Biocontained Carcass Composting for Control of Infectious Disease Outbreak in Livestock

Published on: May 6, 2010

Area of Science:

Public Health
Epidemiology
Immunization Programs

Background:

Neisseria meningitidis serogroup B (MenB) outbreaks have occurred on US college campuses.
A MenB outbreak in Oregon involved 7 cases and 1 fatality over 5 months.

Purpose of the Study:

To discuss the preparation, challenges, and resources for a mass immunization campaign during a university MenB outbreak.
To evaluate the effectiveness of a reactive mass immunization strategy.

Main Methods:

Organized and implemented 4 "opt-in" immunization clinics in response to the outbreak.
Documented logistical challenges and resource expenditures.

Main Results:

The mass immunization campaign faced significant organizational and resource demands.
The outbreak response highlighted the complexities of reactive vaccination efforts.

Conclusions:

Proactive, routine immunization of incoming students is the most effective strategy for MenB outbreak prevention.
Mass immunization campaigns are resource-intensive and logistically challenging during outbreaks.