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Related Experiment Video

Updated: Feb 2, 2026

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
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Working Memory Training in Alcohol Use Disorder: A Randomized Controlled Trial.

Lotfi Khemiri1,2, Christoffer Brynte1,2, Angela Stunkel1,2

  • 1Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.

Alcoholism, Clinical and Experimental Research
|November 22, 2018
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Summary

Working memory (WM) training improved cognitive function in individuals with alcohol use disorder (AUD). While WM training showed a trend toward reducing drinks per occasion, it did not significantly impact heavy drinking or other cognitive skills.

Keywords:
Alcohol Use DisorderCogmedCognitive TrainingWorking Memory

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Addiction Medicine

Background:

  • Alcohol use disorder (AUD) is linked to cognitive impairments, particularly in executive functions, which can hinder recovery and treatment success.
  • Working memory (WM) training is explored as a novel intervention to enhance cognitive abilities and potentially reduce alcohol consumption.

Purpose of the Study:

  • To investigate the efficacy of active working memory (WM) training in improving cognitive functions and reducing alcohol use in patients with AUD.
  • To assess the impact of WM training on heavy drinking, craving, and broader neuropsychological performance.

Main Methods:

  • A randomized controlled trial involving 50 patients with AUD who received either active WM training or control training over 5 weeks.
  • Training was conducted online at home, with weekly follow-up visits.
  • Primary outcomes included changes in WM function and self-reported heavy drinking.

Main Results:

  • Participants undergoing active WM training showed significant improvements in verbal WM compared to the control group.
  • No statistically significant effect was observed on the primary outcome of heavy drinking, though a trend suggested a reduction in drinks per drinking occasion.
  • WM training did not yield statistically significant effects on other neuropsychological tasks or craving.

Conclusions:

  • Cognitive training, specifically WM training, is feasible and can enhance WM function in individuals with AUD.
  • Current evidence does not support WM training as a standalone treatment for reducing heavy drinking or as a method for cognitive transfer in this population.
  • Future research should explore WM training as an adjunctive therapy alongside established AUD treatments to evaluate potential synergistic effects.