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Updated: Feb 2, 2026

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Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
Published on: September 10, 2017
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Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed
Katrina Lichauco1, Mark S Lee1, Michael S Kuhns2
1Department of Immunobiology, The University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Immunity
|November 22, 2018
Abstract:
How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states.
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