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Anionic Long-Circulating Quantum Dots for Long-Term Intravital Vascular Imaging.

Haolu Wang1, Haotian Yang2, Zhi Ping Xu3

  • 1Therapeutics Research Group, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD 4102, Australia. h.wang21@uq.edu.au.

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Mercaptosuccinic acid (MSA) capped quantum dots (QDs) enable high-resolution, long-term in vivo vascular imaging for up to 36 hours. This breakthrough allows visualization of liver vasculature in normal and cancerous conditions.

Keywords:
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Area of Science:

  • Biomedical Imaging
  • Nanotechnology
  • Cancer Research

Background:

  • Long-term in vivo vascular imaging is limited by a lack of suitable probes and contrast agents.
  • Ultrasmall quantum dots (QDs) offer potential for advanced imaging applications due to their unique optical properties.

Purpose of the Study:

  • To develop and evaluate mercaptosuccinic acid (MSA) capped cadmium telluride/cadmium sulfide (CdTe/CdS) QDs for high-resolution, long-term intravital vascular imaging.
  • To visualize and compare liver vasculature in normal and cancerous conditions using these novel QDs.

Main Methods:

  • Synthesis of MSA-capped CdTe/CdS ultrasmall QDs with high fluorescence quantum yield and long blood half-life.
  • Intravenous injection of QDs in mice for in vivo imaging.
  • Utilized multiphoton microscopy (MPM) combined with fluorescence lifetime imaging (FLIM) for high-resolution imaging up to 36 hours post-injection.

Main Results:

  • Demonstrated high-resolution (~1 µm) visualization of mouse liver vasculature up to 36 hours after QD injection.
  • Successfully differentiated between the highly regulated sinusoids in normal liver and the disordered, tortuous neovessels in tumors.
  • Observed long fluorescence lifetime and long half-life of QDs in blood, facilitating prolonged imaging.

Conclusions:

  • MSA-capped CdTe/CdS QDs are effective probes for high-resolution, long-term in vivo vascular imaging.
  • The developed imaging approach can distinguish between normal and cancerous liver vasculature.
  • These imaging methods show significant potential for cancer diagnosis and treatment response monitoring.