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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
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Subclinical Saccadic Eye Movement Dysfunction in Pediatric Multiple Sclerosis.

Andrew Yousef1, Michael Devereux1, Pierre-Antoine Gourraud2,3

  • 11 Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Journal of Child Neurology
|November 23, 2018
PubMed
Summary
This summary is machine-generated.

Eye-tracking effectively detects efferent visual dysfunction in pediatric multiple sclerosis (MS). Children with MS showed longer saccadic latencies, indicating early visual pathway involvement, even with mild disease.

Keywords:
antisaccadeseye-trackingmultiple sclerosispediatricssaccades

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Area of Science:

  • Ophthalmology
  • Neurology
  • Pediatrics

Background:

  • Efferent visual dysfunction in children can negatively impact daily life and academic performance.
  • Eye-tracking technology offers a sensitive method to detect subtle visual impairments not apparent during bedside examinations.
  • This technology's utility has not been previously established in pediatric multiple sclerosis (MS).

Purpose of the Study:

  • To assess the feasibility of using eye-tracking in children diagnosed with multiple sclerosis.
  • To investigate the association between eye-tracking metrics and multiple sclerosis in pediatric patients.

Main Methods:

  • Recruited pediatric multiple sclerosis patients without acute visual abnormalities and age-matched healthy controls.
  • Utilized saccade and antisaccade testing paradigms with eye-tracking technology.
  • Employed generalized estimating equations to compare saccadic and antisaccadic latencies between groups, adjusting for age and clinical factors like Expanded Disability Status Scale (EDSS) and Symbol Digit Modalities Test (SDMT) scores.

Main Results:

  • Fifteen children with pediatric MS (30 eyes) and 6 healthy controls (12 eyes) were eye-tracked.
  • High intertest repeatability (Intraclass correlation coefficient = 0.85) was observed.
  • Children with MS exhibited significantly longer saccadic latencies (60 ms longer) compared to controls (P = .0005), with a similar trend for antisaccadic latencies (P = .06).

Conclusions:

  • Eye-tracking is a feasible, non-invasive tool with high repeatability for pediatric MS research.
  • Longer saccadic latencies in children with MS suggest early efferent visual pathway involvement, even with short disease duration and low EDSS scores.