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Association between chronic obstructive pulmonary disease and serum lipid levels: a meta-analysis
Lingling Xuan1, Feifei Han1, Lili Gong1
1Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Lipids in Health and Disease
|November 23, 2018
Summary
This meta-analysis found no significant differences in lipid profiles between patients with chronic obstructive pulmonary disease (COPD) and healthy individuals. However, excluding dyslipidemia treatments, COPD patients showed higher triglyceride levels, suggesting a need for screening.
Area of Science:
- Pulmonary Medicine
- Cardiovascular Medicine
- Metabolic Disorders
Background:
- Metabolic syndrome is a frequent comorbidity in patients with chronic obstructive pulmonary disease (COPD).
- The association between COPD and dyslipidemia, a key component of metabolic syndrome, remains unclear.
- This study investigates the relationship between COPD and serum lipid levels: HDL, LDL, TC, and TG.
Purpose of the Study:
- To conduct a meta-analysis on the association between COPD and serum lipid profiles.
- To clarify the ambiguous relationship between COPD and dyslipidemia.
- To determine if COPD influences levels of HDL, LDL, TC, and TG.
Main Methods:
- Searched PubMed and Embase databases for studies on dyslipidemia and COPD.
- Included 11 studies with 615 COPD cases and 471 controls.
- Performed subgroup analysis excluding patients on dyslipidemia treatment, using random effects models.
Main Results:
- Overall, no significant differences in HDL, LDL, TC, or TG levels were found between COPD patients and controls.
- Subgroup analysis of patients not receiving dyslipidemia treatment revealed significantly higher TG levels in stable COPD patients.
- COPD patients without dyslipidemia treatment had elevated triglycerides (MD = 16.35, P = 0.002).
Conclusions:
- After excluding the effect of lipid-lowering treatments, triglyceride levels are higher in COPD patients.
- Physicians should consider screening COPD patients for elevated TG levels.
- Managing high TG levels in COPD patients may reduce cardiovascular risks.
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