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A time-resolved multi-omic atlas of the developing mouse stomach
Xianju Li1, Chunchao Zhang2, Tongqing Gong1
1State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (The PHOENIX Center, Beijing), Beijing, 102206, China.
Nature Communications
|November 23, 2018
Summary
This study maps mouse stomach development at the molecular level, revealing three distinct phases. Findings link developmental proteins to diffuse-type gastric cancer, offering insights into tumorigenesis.
Area of Science:
- Developmental Biology
- Molecular Biology
- Genomics and Proteomics
Background:
- Mammalian stomach structure is diverse, with development crucial for function.
- Previous research focused on morphology, lacking system-wide molecular analysis of stomach development.
Purpose of the Study:
- To create a comprehensive temporal proteome and transcriptome atlas of mouse stomach development.
- To identify molecular changes and phases during stomach organogenesis.
- To explore the connection between stomach development and gastric cancer.
Main Methods:
- Quantitative proteomic and transcriptomic analysis of mouse stomach across multiple developmental stages.
- Identification and validation of novel splicing junction transcripts.
- Differential expression analysis of proteins and RNAs.
Main Results:
- A temporal atlas of 12,108 gene products identified three distinct developmental phases.
- Transcriptome analysis revealed functionally important isoforms and novel splicing transcripts.
- Proteins differentially expressed during stomach development are also overexpressed in diffuse-type gastric cancer.
Conclusions:
- This study provides a valuable resource for understanding mammalian stomach development.
- The findings highlight molecular links between normal development and gastric cancer pathogenesis.
- Identified molecular signatures can inform future research on stomach cancer and development.
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