Related Experiment Video

Updated: Feb 2, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

14.2K

An insight into new strategies to combat antifungal drug resistance

Yan-Hua Zheng1, Yue-Yun Ma2, Yi Ding3

  • 1Department of Hematology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China, gaoguangxun@fmmu.edu.cn; xiequnchen@fmmu.edu.cn.

Drug Design, Development and Therapy
|November 23, 2018
PubMed

Insights

Antifungal drug resistance is increasing, threatening immunocompromised patients. This review explores new therapeutic targets and novel antifungal agents to combat rising resistance and improve treatment outcomes.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Invasive fungal infections (IFIs) are a major cause of mortality, particularly in immunocompromised individuals.
  • Current antifungal drugs (triazoles, echinocandins, polyenes) face increasing resistance, limiting treatment efficacy.
  • The limited arsenal of antifungals exacerbates drug resistance and treatment refractoriness.

Purpose of the Study:

  • To explore novel therapeutic strategies and targets for overcoming antifungal drug resistance.
  • To provide clinical evidence for combination therapy using conventional and novel antifungal agents.
  • To introduce emerging antifungal agents with new mechanisms of action.

Main Methods:

  • Review of current literature on antifungal drug resistance mechanisms.
  • Highlighting therapeutic strategies targeting heat shock protein 90 (Hsp90), calcineurin, trehalose biosynthesis, and sphingolipid biosynthesis.
  • Introduction of novel antifungal agents like carboxymethyl chitosan, silver nanoparticles, and chromogranin A-N46.

Main Results:

  • Identification of key molecular targets (Hsp90, calcineurin, etc.) for novel antifungal therapies.
  • Rationale for combining existing antifungals with agents that have novel mechanisms of action.
  • Overview of promising new antifungal compounds with potential clinical applications.

Conclusions:

  • Targeting specific pathways like Hsp90 and calcineurin offers potential to overcome drug resistance.
  • Combination therapies hold promise for enhancing efficacy against invasive fungal infections.
  • Novel antifungals such as carboxymethyl chitosan, silver nanoparticles, and chromogranin A-N46 represent future therapeutic avenues.
Keywords:
Hsp90calcineurincarboxymethyl chitosanchromogranin A-N46sphingolipidstrehalose

More Related Videos

Candida albicans Biofilm Chip CaBChip for High-throughput Antifungal Drug Screening08:05

Candida albicans Biofilm Chip CaBChip for High-throughput Antifungal Drug Screening

Published on: July 18, 2012

14.2K
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

11.2K

Related Concept Videos

Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K
Equivalent Resistance01:16

Equivalent Resistance

In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
983
Resistance and Conductance01:25

Resistance and Conductance

A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
513
Rolling Resistance01:21

Rolling Resistance

When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
662
Vascular Resistance01:20

Vascular Resistance

Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
10.9K