Related Experiment Video

Updated: Feb 2, 2026

In Vivo Mouse Model of Spinal Implant Infection
08:03

In Vivo Mouse Model of Spinal Implant Infection

Published on: June 23, 2020

2.8K

Effect of intrawound vancomycin application in spinal surgery on the incidence of surgical site infection: a

Abuduwufuer Tailaiti1, Jun Shang2, Shuo Shan3

  • 1Department of Orthopedic Surgery, Urumqi Friendship Hospital, Xinjiang 86830049, China.

Therapeutics and Clinical Risk Management
|November 23, 2018
PubMed
Abstract

Insights

Intrawound vancomycin significantly reduces surgical site infections (SSI) after spine surgery, particularly when internal fixation is used. This method is a valuable tool for preventing postoperative infections in spinal procedures involving instrumentation.

Area of Science:

  • Orthopedic Surgery
  • Infectious Disease Prevention
  • Pharmacology

Background:

  • Surgical site infection (SSI) remains a significant complication following spine surgery.
  • Intrawound vancomycin application is a debated strategy for SSI prevention.

Purpose of the Study:

  • To systematically review and analyze the effectiveness of intra-wound vancomycin powder in preventing postoperative SSI.
  • To evaluate the impact of intrawound vancomycin on SSI rates in various spinal surgery contexts.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, Medline, Elsevier, and CNKI.
  • Keywords included "vancomycin," "local/intraoperative/topical/intra-wound," "spine/spinal/lumbar/cervical/thoracolumbar surgery," "infection," and "SSI."
  • Data from 27 studies (17,321 patients) were analyzed using RevMan 5.3.

Main Results:

  • Intrawound vancomycin application was associated with a statistically significant reduction in SSI incidence (0.39 times that of control groups, P<0.01).
  • Vancomycin significantly lowered SSI rates in patients undergoing internal fixation (OR 0.31, P<0.01).
  • No significant effect on SSI incidence was observed in patients without internal fixation (P=0.17) or those undergoing deformity correction (P=0.25).

Conclusions:

  • Intrawound vancomycin application is effective in reducing SSI incidence in most spinal surgery scenarios.
  • This method is particularly beneficial for preventing postoperative SSI in spinal procedures that involve instrumentation.
Keywords:
intrawoundmeta-analysispreventionspinal surgerysurgical site infectionvancomycin

More Related Videos

Intraoperative Ultrasound in Spinal Surgery05:53

Intraoperative Ultrasound in Spinal Surgery

Published on: August 17, 2022

5.4K
Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection09:09

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

9.4K

Related Concept Videos

Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.9K
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
1.4K
Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
Types of Reports II: Incident or Occurrence Report01:21

Types of Reports II: Incident or Occurrence Report

An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
1.3K
Spinal Cord01:26

Spinal Cord

The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
1.9K
meta-Directing Deactivators: &ndash;NO2, &ndash;CN, &ndash;CHO, &ndash;&NoBreak;CO2R, &ndash;COR, &ndash;CO2H01:13

meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H

All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
6.7K