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Visualization of Intensity Levels to Reduce the Gap Between Self-Reported and Directly Measured Physical Activity
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Are patient-reported outcomes of physical function a valid substitute for objective measurements?
J A J Douma1, H M W Verheul1, L M Buffart1,2
1Department of Medical Oncology, Cancer Center Amsterdam, Netherlands.
Current Oncology (Toronto, Ont.)
|November 23, 2018
Summary
Patient-reported physical function outcomes are weakly associated with objective measures in cancer survivors. These patient-reported outcomes cannot replace objective tests for assessing physical function in clinical practice.
Area of Science:
- Oncology
- Rehabilitation Medicine
- Exercise Physiology
Background:
- Physical function is crucial for cancer treatment strategies and can be assessed via patient-reported outcomes (PROs).
- Objective measures of physical activity and fitness exist but are labor-intensive and rarely used clinically.
- This study investigates the accuracy of PROs for physical function (PRO-PF) against objective measures in cancer patients post-treatment.
Purpose of the Study:
- To determine if PROs for physical function accurately predict objective physical function.
- To examine the interrelationships between PRO-PF, physical activity, and cardiorespiratory fitness in cancer survivors.
- To assess the clinical utility of PRO-PF as a substitute for objective physical function assessments.
Main Methods:
- Utilized baseline data from the REACT and EXIST studies involving cancer patients post-chemotherapy or stem-cell transplantation.
- Assessed interrelationships between PRO-PF (EORTC QLQ-C30 physical function subscale), physical activity (accelerometer), and cardiorespiratory fitness (peak oxygen uptake).
- Employed univariable and multivariable linear mixed-effects models, adjusting for age, sex, and BMI.
Main Results:
- PRO-PF showed a significant but weak association with objective physical activity (β = 1.75) and cardiorespiratory fitness (β = 0.10) after adjustments.
- Standardized coefficients (0.28 for physical activity, 0.26 for fitness) indicate a weak predictive relationship.
- The findings suggest limited concordance between subjective and objective physical function assessments.
Conclusions:
- Patient-reported physical function outcomes demonstrate a weak correlation with objective measures of physical activity and fitness in cancer survivors.
- PRO-PF is not a reliable substitute for objective physical function assessments in clinical practice for this population.
- Objective evaluation of physical activity and fitness remains essential for comprehensive assessment in cancer rehabilitation.
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