Related Experiment Video
Updated: Feb 2, 2026

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft
Published on: February 14, 2022
Coronary CTA for Surveillance of Cardiac Allograft Vasculopathy
Nishant R Shah1, Ron Blankstein2, Todd Villines3
11Lifespan Cardiovascular Institute, Division of Cardiovascular Medicine, Dept. of Medicine, Brown University Alpert Medical School, Providence, RI USA.
Purpose Of Review:
The purpose of this review is to highlight recent hardware and software advances in coronary computed tomography angiography (CTA) that make it a potentially viable alternative to invasive coronary angiography for surveillance of cardiac allograft vasculopathy (CAV) in heart transplant recipients.
Recent Findings:
Dual-source CT, multisegment reconstruction, and intracycle motion correction algorithms are all technologies applied during or after image acquisition that can improve image quality and diagnostic accuracy in patients with elevated heart rates, such as heart transplant recipients. CT fractional flow reserve may also add value in this clinical scenario.
Summary:
Coronary CTA now has equivalent diagnostic accuracy, offers more nuanced anatomic information, is inherently safer, and could be less costly than invasive coronary angiography. For these reasons, coronary CTA may now be a viable alternative to ICA for CAV surveillance in heart transplant recipients.
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