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Bone Microdamage in Acute Knee Injury.

Logeswaran Selvarajah1, Annie M Curtis2, Oran D Kennedy3

  • 1Department of Anatomy, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland. logesselva@rcsi.ie.

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|November 23, 2018
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Summary
This summary is machine-generated.

Bone microdamage, particularly in the subchondral bone, is closely linked to bone marrow lesions (BMLs) after acute joint injury. This connection may explain subsequent joint degeneration and pain.

Keywords:
Bone marrow lesionCrosstalkJoint injuryMicrodamageSubchondral bone

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Area of Science:

  • Orthopedics
  • Bone Biology
  • Radiology

Background:

  • Bone tissue responds to microdamage through targeted remodeling.
  • Subchondral bone is susceptible to microdamage, especially after acute joint injury.
  • Bone marrow lesions (BMLs) are frequently observed via MRI following acute knee injuries.

Purpose of the Study:

  • To review the current understanding of bone tissue's response to microdamage.
  • To explore the relationship between subchondral microdamage and BMLs.
  • To discuss the implications for acute joint injury and subsequent joint degeneration.

Main Methods:

  • Literature review of studies on bone microdamage and BMLs.
  • Analysis of MRI findings in acute joint injuries.
  • Discussion of potential pathomechanisms linking microcracks and BMLs.

Main Results:

  • Microcracks in bone initiate osteocyte-mediated remodeling via RANKL expression.
  • Subchondral microcracks observed via MRI correlate spatially with BMLs.
  • BMLs are associated with joint pain and progressive structural joint degeneration.

Conclusions:

  • Subchondral microcracks are likely initiated during acute joint injury.
  • These microcracks are closely associated with clinically observed BMLs.
  • The link between microcracks and BMLs suggests a role in post-injury joint degeneration.