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Survivin c.-31G>C (rs9904341) gene transversion and urinary system cancers risk: a systematic review and a
Tahereh Mazoochi1, Mohammad Karimian2, Hassan Ehteram2
1Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Aim:
To investigate the possible association between survivin c.-31G>C (rs9904341) gene polymorphism and urinary system cancers by a meta-analysis approach.
Methods:
Standard electronic literature databases were searched to find eligible studies. The odds ratios (ORs) with 95% CIs were estimated to find the associations possibility.
Results:
Overall meta-analysis revealed significant associations between c.-31G>C transversion and risk of urinary tract cancers in dominant (OR: 1.34; 95% CI: 1.02-1.75; p = 0.035), recessive (OR: 1.52; 95% CI: 1.33-1.74; p < 0.001) and homozygote codominant (OR: 1.90; 95% Cl: 1.37-2.62; p < 0.001) genetic models.
Conclusion:
The c.-31G>C transversion might be a risk factor for urinary system cancers. However, more articles with different ethnicities will help to obtain a more accurate conclusion.
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