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Progresses in microRNA Delivery Using Synthetic Nanovectors in Cancer Therapy

Sanaz Javanmardi1, Mahmoud Reza Aghamaali1, Samira Sadat Abolmaali2

  • 1Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran.

Current Pharmaceutical Design
|November 23, 2018
PubMed

Insights

MicroRNAs hold promise for cancer therapy but face delivery challenges. Nanotechnology-based delivery systems are improving microRNA (miRNA) efficacy by overcoming biological barriers for advanced anti-cancer drug development.

Area of Science:

  • Molecular Biology
  • Nanotechnology
  • Oncology

Background:

  • MicroRNAs (miRNAs) are crucial noncoding RNAs regulating gene expression.
  • Aberrant miRNA expression is linked to cancer, presenting therapeutic potential.
  • Current miRNA delivery faces barriers like low uptake, degradation, and immune response.

Purpose of the Study:

  • To review recent advancements in nanotechnology-based delivery systems for miRNA cancer therapy.
  • To categorize delivery systems based on miRNA molecules and their therapeutic applications.
  • To highlight challenges and achievements in overcoming delivery barriers.

Main Methods:

  • Review of current literature on nanotechnology-based miRNA delivery systems.
  • Categorization of delivery vehicles (viral, synthetic, targeted) for miRNA therapeutics.
  • Analysis of miRNA delivery efficiency, cellular uptake, endosomal escape, and cytotoxicity.

Main Results:

  • Nanotechnology offers solutions to miRNA delivery barriers, enhancing therapeutic efficiency.
  • Targeted delivery systems improve cellular uptake and reduce off-target effects.
  • Various systems demonstrate potential for improved anti-cancer efficacy with low toxicity.

Conclusions:

  • Nanotechnology-based delivery systems are critical for advancing miRNA cancer therapy.
  • Overcoming biological barriers is key to successful miRNA drug development.
  • Further research is needed for clinical translation of these advanced delivery systems.
Keywords:
cancer therapycombination therapydelivery systemgene expressionmicroRNArenal filtration.

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