Getting Too Old Too Quickly for Their Job: Senescent Glial Cells Promote Neurodegeneration
David Gosselin1, Serge Rivest1
1Neuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Université Laval, Quebec City, QC G1V 4G2, Canada.
Neuron
|November 23, 2018
Abstract:
In a provocative study recently published in Nature, Bussian et al. (2018) report that in tauopathies, glial cells, but not neurons, may be prone to enter cell senescence. Importantly, eliminating senescent glial cells preserves neuronal functions and prevents cognitive decline.
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