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Related Experiment Videos

Elevated corneal epithelial lines in Acanthamoeba keratitis.

G J Florakis1, R Folberg, J H Krachmer

  • 1Iowa Lions Cornea Center, University of Iowa Hospitals and Clinics, Iowa City 52242.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|September 1, 1988
PubMed
Summary
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Acanthamoeba infections can cause elevated corneal epithelial lines in contact lens wearers using improper lens care. Histopathology confirms Acanthamoeba presence in these lines, highlighting a significant clinical sign.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Acanthamoeba keratitis is a severe microbial infection of the cornea.
  • Contact lens wear, particularly with improper disinfection, is a major risk factor.
  • Elevated corneal epithelial lines represent a distinct clinical manifestation.

Observation:

  • Two patients with Acanthamoeba keratitis presented with elevated corneal epithelial lines.
  • Both patients used soft contact lenses and disinfected them with distilled water and salt tablets.
  • Histopathological analysis of the epithelial lines revealed Acanthamoeba trophozoites and cysts.

Findings:

  • Acanthamoeba castellani and Acanthamoeba polyphaga were identified via culture from epithelial lines and conjunctiva in one patient post-keratoplasty.

Related Experiment Videos

  • In the second patient, corneal epithelial lines developed one month after symptom onset without penetrating keratoplasty.
  • The study confirms Acanthamoeba presence within these characteristic corneal lesions.

    • Implications:

    • Elevated corneal epithelial lines are a significant clinical indicator of Acanthamoeba keratitis.
    • Improper contact lens hygiene, including the use of distilled water, increases infection risk.
    • Early recognition of these lines may aid in timely diagnosis and treatment of Acanthamoeba infections.