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Racial differences in atopic dermatitis.

Patrick M Brunner1, Emma Guttman-Yassky2

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PubMed
Summary
This summary is machine-generated.

Atopic dermatitis (AD) shows significant ethnic and racial variations in prevalence and disease presentation. Genetic factors like FLG mutations and immune responses differ across populations, impacting treatment strategies.

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Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Atopic dermatitis (AD) is a common inflammatory skin condition with varying prevalence globally.
  • Understanding ethnic and racial differences in AD is crucial for effective management.

Purpose of the Study:

  • To synthesize research on ethnic and racial disparities in atopic dermatitis (AD) epidemiology.
  • To examine clinical features, skin, and blood phenotypes across diverse populations.

Main Methods:

  • Comprehensive literature review of PubMed-indexed articles.
  • Focus on studies published between 2000 and 2018.
  • Inclusion of research primarily on human subjects with AD.

Main Results:

  • Higher AD rates observed in Africa and Oceania compared to India and parts of Europe.
  • In the US, African American children had higher AD prevalence (19.3%) than European American children (16.1%).
  • Filaggrin (FLG) mutations are less common in African Americans, suggesting a reduced role in AD pathogenesis in this group.
  • While all groups show TH2 activation, distinct immune profiles exist: Asians exhibit stronger TH17/TH22 responses, and African Americans show higher IgE levels with less TH1/TH17 activation.

Conclusions:

  • Atopic dermatitis (AD) is a heterogeneous condition with significant ethnic and racial variations.
  • These differences in epidemiology, genetics, and immune responses are vital for developing targeted therapies.
  • Personalized medicine approaches for AD should consider patient ethnicity and race.