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Clinical study on hemoporfin PDT for infant facial port-wine stains

Yunjie Zhang1, Yuguang Yang1, Zhe Zhang1

  • 1Department of Dermatology of First Affiliated Hospital of PLA General Hospital, Beijing, 100048, China.

Photodiagnosis and Photodynamic Therapy
|November 23, 2018
PubMed

Insights

Hemoporfin photodynamic therapy (PDT) effectively treats infant facial port-wine stains (PWS), showing a 98% efficacy rate. Adverse reactions were minimal, indicating a safe and beneficial therapeutic option.

Area of Science:

  • Dermatology
  • Photomedicine
  • Pediatric Medicine

Background:

  • Infant facial port-wine stains (PWS) present a significant cosmetic and psychological concern.
  • Photodynamic therapy (PDT) offers a potential treatment modality for vascular lesions.

Purpose of the Study:

  • To evaluate the clinical efficacy and therapeutic response of Hemoporfin photodynamic therapy (PDT) for infant facial port-wine stains (PWS).

Main Methods:

  • 100 infant cases with facial PWS were treated using Hemoporfin PDT.
  • Treatment involved intravenous Hemippofen injection followed by irradiation with 532 nm LED green light.
  • Therapeutic response and clinical efficacy were monitored via a digital consulting platform.

Main Results:

  • An overall effective rate of 98% was achieved.
  • Common transient side effects included itching (85%), edema (100%), purpura-like changes (89%), and crusting (33%).
  • Minimal long-term adverse effects were observed, with hyperpigmentation and scarring in 2% of cases, and no systemic reactions.

Conclusions:

  • Hemoporfin PDT demonstrates high clinical efficacy and a favorable response rate for treating infant facial PWS.
  • The treatment is associated with generally mild and transient adverse reactions, making it a viable option for this pediatric population.
Abstract

Keywords:
HemoporfinInfantPDTPWSPort wine stains

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