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Updated: Feb 2, 2026

Gold Nanoparticle Synthesis
Published on: July 10, 2021
Investigation of antisolvent effect on gold nanoparticles during postsynthesis purification
Min He1, Xiaofang Liu1, Bin Liu1
1Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry & Materials Science, Northwest University, Xi'an 710127, People's Republic of China.
Abstract:
Gold nanoparticles (Au NPs) were synthesized by reducing HAuCl4 using borane tert-butylamine complex in the presence of alkylamine (dodecylamine, hexadecylamine, and octadecylamine) and didodecyldimethylammonium bromide. Ethanol was used as an antisolvent for the postsynthesis purification of Au NPs. Au NPs had uniform size distribution after first wash with ethanol and the aggregation and growth of Au NPs happened after second wash with ethanol. The Au NPs were characterized by TEM, SEM, XRD, 1H NMR, UV-vis absorption and FTIR spectroscopy. The aggregated mechanism after the second wash with ethanol was proposed. Au NPs still retained their monodispersity after second wash compared with after first wash using the antisolvents, such as acetonitrile, dimethyl sulfoxide and acetone. The presented results suggest that the good choice of antisolvent is critical for the postsynthesis purification of Au NPs.
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