Korean Medication Algorithm Project for Bipolar Disorder 2018 (KMAP-BP 2018): Fourth Revision.
Young Sup Woo1, Won-Myong Bahk1, Jung Goo Lee2,3
1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Summary
The Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) 2018 updates treatment guidelines for bipolar disorder based on expert consensus. It offers revised strategies for mania and depression, aiding clinical decision-making.
Area of Science:
- Psychiatry
- Pharmacology
- Clinical Neuroscience
Background:
- The Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) has been periodically updated since 2002.
- This study represents the fourth revision, incorporating the latest expert consensus on bipolar disorder pharmacotherapy.
Purpose of the Study:
- To revise and update the KMAP-BP guidelines for the pharmacological treatment of bipolar disorder.
- To provide current, evidence-based recommendations for clinicians treating adult and pediatric bipolar disorder.
Main Methods:
- A comprehensive 50-item questionnaire was distributed to experts.
- Expert consensus was gathered from 84 Korean psychiatrists and 43 child and adolescent psychiatry experts.
- The consensus focused on pharmacological treatment strategies across different phases of bipolar disorder.
Main Results:
- For acute mania, preferred first-step strategies include mood stabilizer (MS) + atypical antipsychotic (AAP) combination, MS monotherapy, or AAP monotherapy.
- For bipolar depression, preferred strategies range from monotherapy (MS, AAP, lamotrigine) to various combinations depending on severity and psychotic features.
- Specific combinations were recommended for psychotic mania and severe depression, including options with antidepressants.
Conclusions:
- The KMAP-BP 2018 recommendations reflect recent advancements in bipolar disorder pharmacotherapy.
- This updated algorithm provides clinicians with valuable guidance for effective patient treatment strategies.
Related Concept Videos
01:30Bipolar Disorder
746
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
746
02:18Fischer Projections
16.6K
Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
16.6K
02:06Newman Projections
21.0K
Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
21.0K
01:22Bipolar Junction Transistor
1.5K
Bipolar Junction Transistors (BJTs) are essential elements in electronic circuits, playing a crucial role in the functionality of amplifiers, memories, and microprocessors. These transistors can be designed as NPN or PNP based on their doping patterns. They consist of three layers: the emitter, base, and collector. The configuration of these layers and their respective doping levels—with N-type or P-type impurities—define the transistor's type and its operational...
1.5K
01:12Trial and Error and Algorithm
411
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
411
01:23Inhaled Medications
800
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
800