Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Transformation01:33

Bacterial Transformation

59.9K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
59.9K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

3.2K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.2K
Bacterial Signaling01:30

Bacterial Signaling

40.7K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
40.7K
Chronic Pharyngitis01:23

Chronic Pharyngitis

11.9K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
11.9K
Bacterial RNA Polymerase00:43

Bacterial RNA Polymerase

32.8K
Unlike eukaryotes, bacteria use a single RNA Polymerase (RNAP) to transcribe all genes. The different subunits of bacterial RNAPhave distinct functions. The multisubunit structure of the bacterial RNAP helps the enzyme to maintain catalytic function, facilitate assembly, interact with DNA and RNA, and self-regulate its activity.
In most genes, the transcription site is a single base present upstream of the coding sequence. Though RNAP is a catalytically efficient enzyme, it does not recognize...
32.8K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

741
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
741

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunogenicity and safety of co-administration of a recombinant shingles vaccine with an mRNA COVID-19 or adjuvanted influenza vaccine: a randomised controlled trial.

The Journal of infection·2026
Same author

Infection, inflammation and immune dysregulation: evolving perspectives on the host response.

Archives of disease in childhood·2026
Same author

Acute cervical lymphadenitis in a febrile child: when to think beyond infection?

Archives of disease in childhood. Education and practice edition·2026
Same author

How can innovative trials in juvenile idiopathic arthritis serve the unmet needs of patients?

Arthritis research & therapy·2026
Same author

Can targeting IL-1 mediated inflammation improve outcomes after neonatal hypoxic-ischaemic encephalopathy?

Archives of disease in childhood. Fetal and neonatal edition·2026
Same author

Trends in invasive and non-invasive Streptococcus pneumoniae disease in adults hospitalised in Bristol and Bath: a retrospective cohort study, 2006-2022.

BMC infectious diseases·2026
Same journal

Identifying outcome measures for clinical trials in juvenile idiopathic arthritis associated uveitis for the MIWGUC proposal: a scoping review to create domains from existing outcome measures.

Pediatric rheumatology online journal·2026
Same journal

Vaccination coverage and serological follow-up in children with rheumatologic diseases: a retrospective single-centre study.

Pediatric rheumatology online journal·2026
Same journal

Tumor necrosis factor inhibitor-related autoimmune disorders in pediatric rheumatology practice: a multicenter nationwide study.

Pediatric rheumatology online journal·2026
Same journal

Objective evaluation of hand physiotherapy in juvenile systemic sclerosis using the MediTutor robotic glove.

Pediatric rheumatology online journal·2026
Same journal

The use of JAK inhibitors and tocilizumab in the management of TRAPS: a sibling case study.

Pediatric rheumatology online journal·2026
Same journal

Update on clinimetric assessments in juvenile dermatomyositis: conceptual foundations, current tools, and future directions : (Narrative review describing the development, validation, and application of clinimetric outcome measures in juvenile dermatomyositis).

Pediatric rheumatology online journal·2026
See all related articles

Related Experiment Video

Updated: Feb 2, 2026

Introducing Shear Stress in the Study of Bacterial Adhesion
13:28

Introducing Shear Stress in the Study of Bacterial Adhesion

Published on: September 2, 2011

16.2K

Chronic non bacterial osteitis- a multicentre study.

Chandrika S Bhat1, Catriona Anderson2, Aoibhinn Harbinson3

  • 1Departments of Paediatric Rheumatology and Immunology, Bristol Royal Hospital for Children, Bristol, BS2 8BJ, UK.

Pediatric Rheumatology Online Journal
|November 24, 2018
PubMed
Summary
This summary is machine-generated.

This study on Chronic Non-bacterial Osteitis (CNO) in UK children found it affects girls more, with bone pain as a key symptom. Most patients achieved remission with treatments like NSAIDs and bisphosphonates.

Keywords:
Auto inflammatoryBisphosphonatesBristol diagnostic criteriaMultifocalNon-infectious osteitisWhole body magnetic resonance imaging

More Related Videos

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

2.0K
Studies of Bacterial Chemotaxis Using Microfluidics - Interview
10:35

Studies of Bacterial Chemotaxis Using Microfluidics - Interview

Published on: May 28, 2007

8.7K

Related Experiment Videos

Last Updated: Feb 2, 2026

Introducing Shear Stress in the Study of Bacterial Adhesion
13:28

Introducing Shear Stress in the Study of Bacterial Adhesion

Published on: September 2, 2011

16.2K
Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

2.0K
Studies of Bacterial Chemotaxis Using Microfluidics - Interview
10:35

Studies of Bacterial Chemotaxis Using Microfluidics - Interview

Published on: May 28, 2007

8.7K

Area of Science:

  • Paediatric rheumatology
  • Osteitis
  • Inflammatory bone disease

Background:

  • Chronic Non-bacterial Osteitis (CNO) is a rare inflammatory bone disorder.
  • Understanding its demographics and treatment is crucial for effective management.

Purpose of the Study:

  • To analyze the demographics, clinical characteristics, and treatment outcomes of CNO in a UK pediatric cohort.
  • To evaluate diagnostic tools and treatment efficacy for CNO.

Main Methods:

  • Retrospective review of clinical data from 131 children diagnosed with CNO across three UK tertiary pediatric rheumatology centers (2001-2017).
  • Application of Bristol diagnostic criteria.
  • Analysis of symptoms, inflammatory markers, imaging (whole-body MRI), and treatment responses.

Main Results:

  • CNO was more prevalent in girls (2.5:1), with a median onset age of 9.5 years.
  • Bone pain (91.4%) was the primary symptom; distal tibial metaphyses were the most common site (49.6%).
  • First-line treatments included NSAIDs (81.67%) and bisphosphonates (61.79%), with good remission rates (82.4%) and effective use of TNF blockers for refractory cases.

Conclusions:

  • This multicenter study provides comprehensive insights into CNO features and outcomes in a large UK pediatric population.
  • Whole-body MRI is valuable for diagnosis and monitoring treatment response.
  • Standard treatments, including NSAIDs and bisphosphonates, are effective, with TNF blockers offering a good alternative for non-responders.