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A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage
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Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility?
1Sheffield Kidney Institute, Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK.
Abstract:
Peritoneal dialysis technique survival remains challenging due to peritonitis and long-term alterations to peritoneal membrane function and integrity. Up to now, the development of less bio-incompatible dialysis solutions have not had a major impact on these aspects of the therapy. A novel approach, supplementing dialysis solutions with a cytoprotective additive, alanyl-glutamine, has shown benefits to surrogate biomarkers of cell function in a randomized controlled study.
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