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Efficacy of linalool to ameliorate uremia induced vascular calcification in wistar rats

Tanzeer Kaur1, Sunaina Kaul1, Ankita Bhardwaj1

  • 1Department of Biophysics, Panjab University, Chandigarh 160014, India.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|November 24, 2018
PubMed

Insights

Linalool, an essential oil, may prevent vascular calcification in uremia by reducing calcium deposition and oxidative stress. This study suggests linalool as a potential therapeutic for cardiovascular complications in chronic kidney disease patients.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Nephrology

Background:

  • Uremia, a late stage of chronic kidney disease (CKD), is linked to cardiovascular mortality.
  • Hyperphosphatemia in kidney failure promotes vascular smooth muscle cell (VSMC) transdifferentiation and extra-osseous calcification.
  • Vascular calcification (VC) is a significant contributor to cardiovascular complications in CKD patients.

Purpose of the Study:

  • To investigate the potential role of linalool in preventing vascular calcification (VC).
  • To explore the effects of linalool on oxidative stress markers and calcification pathways in uremia.

Main Methods:

  • Uremia was induced in male Wistar rats using adenine and phosphate diets.
  • Linalool was administered orally at doses of 100 mg/kg and 150 mg/kg daily during the phosphate diet phase.
  • Vascular calcification, oxidative stress markers (lipid peroxidation, catalase, SOD), and mRNA expression of calcification markers were assessed.

Main Results:

  • Linalool demonstrated in vitro antioxidant activity by scavenging superoxide radicals.
  • Co-administration of linalool significantly prevented calcium deposition in the aorta of uremic rats.
  • Linalool supplementation reduced elevated mRNA expression of calcification markers, lipid peroxidation, and antioxidant enzymes in uremic rat aortas.

Conclusions:

  • Linalool exhibits anti-calcification properties in the context of uremia.
  • Linalool may mitigate VC by reducing oxidative stress and inhibiting key calcification pathways.
  • Linalool presents a promising therapeutic candidate for clinical investigation in managing VC.
Abstract

Keywords:
Essential oilsLinaloolOxidative stressUremiaVascular calcification

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