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Aminoglycoside nephrotoxicity and urinary excretion of N-acetyl-beta-D-glucosaminidase
J P Langhendries1, O Battisti, J M Bertrand
1Department of Pediatrics, Montegnée-Rocourt, NICU, Clinique Saint-Vincent, Belgium.
Biology of the Neonate
|January 1, 1988
Abstract:
The purpose of this paper is to discuss briefly the mechanism of aminoglycosides nephrotoxicity. This kind of antibiotic seems to act preferentially on the phospholipid metabolism of the proximal tubular cell. A lysosomal enzyme, N-acetyl-beta-D-glucosaminidase, could be of interest in assessing this renal interference.