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Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
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Orthobiologics for Bone Healing.

Jacob G Calcei1, Scott A Rodeo1

  • 1Department of Sports Medicine and Shoulder, Hospital for Special Surgery, 535 E 70th Street, New York, NY 10021, USA.

Clinics in Sports Medicine
|November 24, 2018
PubMed
Summary
This summary is machine-generated.

Orthobiologics enhance healing of bone, muscle, and tendon injuries. This review covers their properties, types, and clinical uses in sports medicine, alongside factors affecting bone healing.

Keywords:
Bone graftingBone healingFracture healingNonunionOrthobiologicsTendon-to-bone

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Area of Science:

  • Orthobiologics and Regenerative Medicine
  • Musculoskeletal Tissue Repair
  • Sports Medicine Innovations

Background:

  • Orthobiologics are biological agents that support the healing of bone, ligament, muscle, and tendon.
  • Available orthobiologics include bone grafts, bone marrow aspirate concentrate, platelet-rich plasma, and growth factors.
  • Key properties for bone healing are osteoconduction, osteoinduction, and osteogenesis.

Purpose of the Study:

  • To review the properties and applications of orthobiologics in bone healing.
  • To discuss current orthobiologic treatments used in sports medicine.
  • To identify systemic factors that impede bone healing.

Main Methods:

  • Literature review of orthobiologics for bone healing.
  • Analysis of properties: osteoconduction, osteoinduction, osteogenesis.
  • Examination of clinical applications in sports medicine.

Main Results:

  • Various orthobiologics promote bone healing through distinct mechanisms.
  • Clinical use in sports medicine is expanding for various musculoskeletal injuries.
  • Systemic factors can significantly inhibit the efficacy of orthobiologics.

Conclusions:

  • Orthobiologics offer promising therapeutic options for musculoskeletal repair.
  • Understanding their properties and applications is crucial for effective clinical use.
  • Addressing systemic factors is essential to optimize orthobiologic treatment outcomes.