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Is it time to routinely incorporate MRD into practice?
1Department of Leukemia, The University of Texas - M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 428, Houston, TX 77030, USA.
Best Practice & Research. Clinical Haematology
|November 24, 2018
Summary
Detecting minimal residual disease (MRD) in acute myeloid leukemia (AML) is crucial but faces challenges. Addressing assay reliability, standardization, and availability is key for routine clinical practice.
Area of Science:
- Hematology
- Oncology
- Clinical Pathology
Background:
- Minimal residual disease (MRD) detection is gaining importance in acute myeloid leukemia (AML) management.
- Routine incorporation of MRD assessment into clinical practice requires addressing several critical issues.
Purpose of the Study:
- To review the challenges and considerations for the routine implementation of MRD assessment in acute myeloid leukemia.
- To highlight the need for robust strategies in MRD detection and leukemia eradication.
Main Methods:
- Literature review of current practices and challenges in MRD detection for AML.
- Analysis of factors influencing the reliability, standardization, and availability of MRD assays.
Main Results:
- Numerous issues impede the routine clinical use of MRD assessment in AML.
- Assay performance, standardization, and accessibility are significant hurdles.
Conclusions:
- Standardization and validation of MRD assays are essential for reliable AML patient monitoring.
- Development of effective strategies to eradicate residual leukemia is paramount for improving patient outcomes.
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