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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Related Experiment Video

Updated: Feb 2, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

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Early-Onset Inflammatory Bowel Disease.

Judith R Kelsen1, Pierre Russo2, Kathleen E Sullivan3

  • 1Division of Gastroenterology, Hepatology and Nutrition, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.

Immunology and Allergy Clinics of North America
|November 24, 2018
PubMed
Summary
This summary is machine-generated.

Inflammatory bowel disease (IBD) incidence is rising, with younger patients often having primary immunodeficiency or monogenic causes. Early diagnosis and genetic insights guide tailored treatments, including transplantation.

Keywords:
InflammationMonogenicPrimary immunodeficienciesVEO-IBD

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Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Genetics

Background:

  • Epidemiology of inflammatory bowel disease (IBD) shows significant changes over 40 years.
  • Increasing incidence and younger age of onset characterize current IBD trends.
  • Early-onset IBD in children is increasingly linked to primary immunodeficiency and monogenic disorders.

Purpose of the Study:

  • To highlight the evolving epidemiology of IBD.
  • To emphasize the association between early-onset IBD and underlying genetic conditions.
  • To underscore the importance of genetic diagnosis in guiding IBD management.

Main Methods:

  • Review of epidemiological data on IBD incidence and age of onset.
  • Analysis of studies identifying genetic causes in pediatric IBD cohorts.
  • Comparison of management strategies based on identified etiologies.

Main Results:

  • IBD incidence has risen dramatically, with a notable decrease in the age of onset.
  • A significant proportion of the youngest IBD patients present with primary immunodeficiency or monogenic causes.
  • Genetic etiologies necessitate distinct therapeutic approaches, differing from typical IBD management.

Conclusions:

  • The changing landscape of IBD, particularly in children, necessitates a focus on underlying genetic and immunodeficiency disorders.
  • Identification of specific genetic causes is crucial for optimizing treatment strategies.
  • Hematopoietic cell transplantation is a viable and effective treatment for select genetic IBD cases.