Related Experiment Video

Updated: Feb 2, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

3.7K

Long-term outcomes after transplantation after support with a pulsatile pediatric ventricular assist device

Aamir Jeewa1, Michiaki Imamura1, Charles Canter1

  • 1Division of Congenital Heart Surgery, Baylor College of Medicine, Houston, TX, US.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|November 24, 2018
PubMed

Insights

Pediatric patients receiving Berlin Heart ventricular assist devices (VAD) as a bridge to heart transplantation showed similar survival and complication rates compared to those not needing mechanical circulatory support (MCS). Further monitoring is recommended.

Area of Science:

  • Pediatric cardiology
  • Cardiac surgery
  • Transplantation medicine

Background:

  • Increasing use of durable ventricular assist devices (VAD) in children as a bridge to transplantation (BTT).
  • The Berlin Heart investigational device exemption (IDE) trial demonstrated excellent survival outcomes for pediatric VAD use as BTT.

Purpose of the Study:

  • Compare post-transplant outcomes in children who received Berlin Heart VADs (BTT) with a matched cohort not requiring mechanical circulatory support (MCS).
  • Evaluate survival, rejection, and infection rates in pediatric heart transplant recipients with and without prior VAD support.

Main Methods:

  • Retrospective review of linked Pediatric Heart Transplant Study (PHTS) and Berlin Heart IDE databases (2007-2011).
  • Matched 83 VAD-supported pediatric recipients (Berlin Heart IDE) 1:2 with 166 non-MCS supported controls from PHTS.
  • Excluded subjects with less than 5 years of follow-up.

Main Results:

  • No significant differences in 5-year patient survival between VAD and non-VAD groups (81% vs. 88%, p=0.09).
  • Similar rates of freedom from rejection and infection were observed between the VAD-supported and non-VAD-supported cohorts.
  • Groups were comparable in diagnosis and age, with expected differences in inotrope use.

Conclusions:

  • Berlin Heart VAD support in pediatric patients resulted in comparable post-transplant survival, infection, and rejection rates versus those not requiring MCS.
  • Continued long-term surveillance of pediatric heart transplant recipients supported by the Berlin Heart VAD is warranted.
Abstract

Keywords:
pediatric end-stage heart failurepediatric heart transplantpediatric mechanical circulatory supportpost transplant survivalventricular assist device

More Related Videos

In Vitro Thrombosis Test for Ventricular Assist Devices09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.2K
Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

9.9K

Related Concept Videos

Self-Help Support Groups01:28

Self-Help Support Groups

Self-help support groups are voluntary, community-based organizations that provide a platform for individuals with shared concerns to exchange support, insights, and practical strategies for coping with life challenges. Typically led by group members or paraprofessionals, these groups form a cornerstone of mental health care, especially in reaching populations that are underserved by traditional healthcare systems.
Accessibility and Cost-Effectiveness
One of the primary strengths of self-help...
355
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.2K
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
Support Reactions01:30

Support Reactions

A coplanar force system refers to a set of forces that all lie in the same plane and are subject to different reactions between the point of contact and the supports. Understanding how different types of supports affect coplanar forces is crucial for designing safe and reliable structures that can withstand external loads.
The purpose of the supports is to prevent the translational motion of the system by applying an equal and opposite force and to prevent the system's rotation by applying...
1.5K
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
3.9K