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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
488
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

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Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
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Rh Blood Group01:19

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The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
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Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Related Experiment Video

Updated: Jan 14, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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ANA-negative systemic lupus erythematosus.

W J Fessel

    The American Journal of Medicine
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Systemic lupus erythematosus (SLE) is typically diagnosed by antinuclear antibody (ANA) tests. This study investigated ten patients with SLE symptoms but negative ANA results, highlighting a potentially overlooked subgroup.

    Area of Science:

    • Immunology
    • Rheumatology
    • Internal Medicine

    Background:

    • Antinuclear antibodies (ANA) are a hallmark diagnostic marker for systemic lupus erythematosus (SLE).

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  • Diagnosis of SLE can be challenging in cases with persistently negative ANA test results despite clinical manifestations.
  • The existence and characteristics of ANA-negative SLE require further investigation.